Hey Doug,

We’ve got an article about this coming out shortly! I’ll update this thread with a link when it’s published.

Best,
Rob

Hey Nick,

Thanks for reaching out.

Firstly, there’s always hope! We’ve seen impressive hair recoveries even for people in advanced stages of hair loss. But as far as setting individual expectations, there’s too much variance to give you a definitive answer here.

I think you’re taking the right steps (at least from a health perspective) in modifying your diet/lifestyle to potentially reduce prostaglandin D2 activity. Scalp massages also help a lot of people. Whether or not this is enough, you should know in 8-12 months. If not, you can always begin to add in additional treatments / interventions – more powerful DHT reducers, etc. – until you find a regimen that works for you.

Best,
Rob

Hey Matt,

Aspirin inhibits the enzyme cyclooxygenase, which is used to make a variety of prostaglandins. The challenge is that some prostaglandins seem to positively regulate the hair cycle, while others seem to negatively affect hair lengthening and maybe even accelerate hair thinning. So, I’m not sure that widespread prostaglandin inhibition is the best answer. And I’d also be concerned about regular aspirin use in relation to the subsequent potential for long-term toxicity.

Best,
Rob

I know many on the Ray Peat forum talk about aspirin being a good inhibitor of the negative prostaglandin, have you read much into the use of aspirin for this?

Thanks
Matt

Hey Donna,

Interestingly, there is a connection between PGD2 receptors and eosinophil trafficking, at least in certain tissues:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000277/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237921/

Is your hair loss more autoimmune in nature, or has it been diagnosed as telogen effluvium, classical female pattern hair loss, or both? The reason I ask is because this would implicate different pathologies in its onset.

If autoimmune, it’s likely more closely related to your morphea / other outstanding health issues. If the latter, it’s more likely a consequence of post-menopausal hormonal shifts (that may exacerbate pre-existing subclinical conditions like hypothyroidism) and/or stress-related, likely the result of a prolonged calorie deficit (as evidenced from your recent weight loss).

Have things gotten better since you last reached out?

Best,
Rob

Hey Moritz — calcification is certainly implicated in AGA, but what makes this more complicated is that there are a variety of different ways a tissue can become calcified. Much of this starts inflammation, but the pathology of that inflammation matters.

For instance, inflammation induced via diet is one way for calcification to begin. Another way: injury. Another way: chronic tension. So treating the calcification with vitamin K2 may help prevent or stave off its progression. However, unless we go back one step further, we might only be putting that process in a “holding” pattern.

Best,
Rob