Comments on: Part 2 Of 4: Attacking DHT By Inhibiting 5-Alpha Reductase https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/ The science of hair loss Sun, 12 Jun 2022 17:45:26 +0000 hourly 1 https://wordpress.org/?v=6.4.1 By: Sebastian https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-114035 Fri, 13 May 2022 14:07:39 +0000 https://perfecthairhealth.com/?p=1538#comment-114035 Hi Rob. But isn’t curucmin will block enzyme that is required for minoxidil conversion into minoxidil sulfate? Im taking oral minoxidil and I’m afraid about it a little.

]]> By: Kira https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-40059 Sun, 30 Dec 2018 10:46:00 +0000 https://perfecthairhealth.com/?p=1538#comment-40059 Hi Rob,

I found you blog lately and I must say the information you provided is very informative. I have a few queries regarding the DHT pathway, which I hope you could throw in some of your ideas.

1) I saw quite a number of finasteride user complain that finasteride induce Telogen Effluvium for such a long time (more than 3 months). Is it even possible and what is your take regarding this ?

2) There has been rumors/theories that, by reducing DHT, the Androgen Receptors on the scalp is getting more and more sensitive and even up-regulate over time and guess what, even a small amount of DHT (the remaining DHT that finasteride failed to block) can still make the us bald faster. What is your take regarding this ?

Many thanks.

]]> By: Exactly How Trans Hormone Replacement Therapy Regrows Hair (Photos) https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-38760 Fri, 27 Jul 2018 19:40:47 +0000 https://perfecthairhealth.com/?p=1538#comment-38760 […] Because Propecia only reduces DHT — not testosterone (in fact, Propecia increases testosterone and estrogen by roughly equal […]

]]> By: Rob https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-13992 Thu, 12 Oct 2017 17:07:11 +0000 https://perfecthairhealth.com/?p=1538#comment-13992 In reply to Jonas.

No worries Jonas! Thanks for letting me know. It’s incredibly frustrating how much misinformation is out there – and it feels like an Atlas task trying sift through it all. Let me know if any other questions comes up. For what it’s worth, curcumin is a powerful anti-inflammatory that likely has other pro-hair benefits outside of DHT reduction.

]]> By: Jonas https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-13973 Thu, 12 Oct 2017 10:11:29 +0000 https://perfecthairhealth.com/?p=1538#comment-13973 In reply to Rob.

Hey Rob,

thanks for taking your time to answer. You’re absolutely correct, the 5 alpha reductase inhibition hasn’t been analysed directly. Got carried away by other sites claiming the DHT blocking effect of curcumin. Thanks for clarification and much appreciation for your work here!

Cheers,
Jonas

]]> By: Rob https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-13649 Sat, 07 Oct 2017 18:48:32 +0000 https://perfecthairhealth.com/?p=1538#comment-13649 In reply to Jonas.

Hey Jonas,

Thanks for reading. I read through your linked study, and it appears the study measured curcumin’s effects on prostate tissue, and its influence of transforming growth factor beta 1, VEGF, and IGF-1. The study demonstrated curcumin’s marked decrease of TGF-B1 and on-par with finasteride’s effect on the same biomarker, but unfortunately, I didn’t see where the study measured curcumin’s effects on 5 alpha reductase.

With that said, this study demonstrates that curcumin reduces inflammatory signaling proteins commonly associated with enlarged prostate diseases, and that’s a great sign. It’s very likely curcumin indirectly decreases 5 alpha reductase by reducing inflammation. So it shouldn’t hurt to take it!

Best,
Rob

]]> By: Jonas https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-13610 Sat, 07 Oct 2017 07:01:30 +0000 https://perfecthairhealth.com/?p=1538#comment-13610 Hey Rob,
very interesting article, thanks for sharing all this!
I was wondering why you haven’t mentioned anything about the 5a-reductase inhibitory effects of curcumin as studied in following research:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618860/
Based on this study the inhibitory effects of curcumin seems to be even greater than Finasteride. Have you heard about it before?
I came across this study when I was thinking of starting a morning routine of taking a daily shot of apple cider vinegar, lemon, ginger, TURMERIC and cayenne pepper mixture (look it up, great stuff).

]]> By: Brooks https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-6977 Sat, 24 Jun 2017 03:20:34 +0000 https://perfecthairhealth.com/?p=1538#comment-6977 Rob,
Great article, I was especially interested in the idea that DHT accumulation may be a result of inflammation triggered by inflammatory signaling proteins already present. Seems like solid evidence showing that DHT and inflammation are not separate, but have a rather causal relationship in pattern hair loss.

This study showed the importance of 5a-reductase inhibition’s importance in reduced volume and inflammation of the prostate gland.

https://www.ncbi.nlm.nih.gov/pubmed/16515494

“By inhibiting the production of dihydrotestosterone (DHT) locally within the prostate gland, 5a-reductase inhibitors have the effect of reducing prostate volume, improving lower urinary tract symptoms, increasing peak urinary flow, and decreasing the risk of acute urinary retention and need for surgical intervention.”

So, when 5a-reductase is inhibited, the less DHT accumulation, which means the tissue becomes less inflamed. The antagonists caused the smooth bladder muscle tissue to relax and become less resistant to urine flow. Knowing that it has this effect on the prostate gland, it could show similar effects in the scalp tissue!

Thanks!

]]> By: Diffuse Hair Thinning? Check Your Zinc Levels (See Photos) — Perfect Hair Health https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-6397 Thu, 25 May 2017 20:44:45 +0000 https://perfecthairhealth.com/?p=1538#comment-6397 […] addition, zinc also decreases the formation of something called NADPH. NADPH is a cofactor our bodies need in order to form the enzyme 5-alpha reductase. In other words […]

]]> By: Reborn Hair PPP https://perfecthairhealth.com/part-2-of-4-a-master-guide-of-the-best-and-worst-ways-to-fight-dht-for-hair-loss/#comment-6037 Wed, 17 May 2017 20:06:26 +0000 https://perfecthairhealth.com/?p=1538#comment-6037 In reply to Paz.

Thanks Dante, Rob, and Paz for the insight. Didn’t know that was the case for Belgravia.

One must very skeptical and careful nowadays to trust sources that appear to be legitimate.

Take care!

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